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Eur J Cardiothorac Surg · Aug 2003
Case ReportsDramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine.
- A Panos, X Orrit, C Chevalley, and A Kalangos.
- Clinic for cardio-vascular surgery, Department of Surgery, University Hospital of Geneva, 24, rue Micheli-du-Crest, 1211 Geneva 14, Switzerland. aristotepanos@yahoo.com
- Eur J Cardiothorac Surg. 2003 Aug 1;24(2):325-7.
AbstractImmunologic reactions to protamine sulfate during cardiac surgery are very rare. The frequency and outcome of such adverse reactions is unclear. We report a case of lethal anaphylactic reaction to protamine that occurred in a non-diabetic patient following the uneventful replacement of the ascending aorta. We also briefly review the mechanisms of this adverse reaction and emit some considerations on the management of this situation.
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