• Alan H Yee and Eelco F M Wijdicks.
• Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. yee.alan@mayo.edu
• Neurocrit Care. 2010 Apr 1;12(2):258-60.

BackgroundSerotonin syndrome is an iatrogenic disorder that results from serotonergic overactivity. Severe myoclonus and increased restlessness are hallmarks of the disorder.MethodsWe report a case of serotonin syndrome related to poor drug elimination.ResultsA 74-year-old white female with moderate to severe Alzheimer's dementia was brought to the emergency department for increasingly aggressive behavior. Upon admission, her risperidone dose was increased and citalopram continued. Several days later, she developed diffuse limb and facial myoclonus, spontaneous clonus, diaphoresis, and fever. Her symptoms completely resolved after discontinuation of these medications.ConclusionSerotonin syndrome should be considered in the differential when elderly patients present with severe myoclonus. If unrecognized, this syndrome can lead to more severe manifestations including rhabdomyolysis, renal failure, and coma.

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