• Noboru Noma, Junad Khan, I-Fang Chen, Stanley Markman, Rafael Benoliel, Emad Hadlaq, Yoshiki Imamura, and Eli Eliav.
• Department of Diagnostic Sciences, Division of Orofacial Pain, New Jersey Dental School, University of Medicine and Dentistry in New Jersey, 110 Bergen Street, Newark, NJ, United States. noma@dent.nihon-u.ac.jp
• Neurosci. Lett. 2011 Apr 15;493(3):86-91.

AbstractIn the present study, we assessed IL-17 levels at 3 and 8 days following various forms of injuries to the sciatic nerve and related the cytokine levels to the pain behaviors associated with the injuries. The four experimental models employed were chronic constriction injury (CCI), partial sciatic ligation (PSL), complete sciatic transection (CST) and perineural inflammation (Neuritis). Behavior withdrawal thresholds for mechanical stimulus and withdrawal latency for thermal stimulation were used to measure mechanical allodynia and thermal hyperalgesia. IL-17 levels of the affected, contralateral and naïve rats' sciatic nerve were assessed employing enzyme-linked immunosorbent assay (ELISA). Rats exposed to CCI and Neuritis displayed significant mechanical allodynia and thermal hyperalgesia 3, 5 and 8 days following the procedure, rats exposed to PSL displayed significant mechanical allodynia 5 and 8 days following the procedure and rats exposed to CST developed significant hypoesthesia. Three days following the procedure, IL-17 levels increased significantly compared to naïve rats only in the PSL model. Eight days following the procedure, IL-17 levels in nerves exposed to CCI, CST, PSL and Neuritis were significantly elevated compare to intact nerve levels. It is likely that IL-17 has a limited role in the acute phase of nerve injury and the associated acute pain, but may have a role in later phases of the processes of the development of neuropathic pain.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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