• Shelan Liu, Jimin Sun, Jian Cai, Ziping Miao, Miaogui Lu, Shuwen Qin, Xiaoxiao Wang, Huakun Lv, Zhao Yu, Said Amer, and Chengliang Chai.
• Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, 630 Xincheng Road, Binjiang District, Hangzhou, Zhejiang 310051, China. Electronic address: liushelan20070429@126.com.
• J. Infect. 2013 Dec 1;67(6):595-605.

BackgroundThe high mortality of avian influenza H7N9 in humans is a cause of great concern in China.MethodsWe compared epidemiological, clinical and viral features of H7N9 influenza of 10 fatal cases and 30 survivors.ResultsIncreasing age (p = 0.021), smoking (p = 0.04), underlying medical background (p = 0.05) and chronic drug use (p = 0.042) had a strong relationship with death due to H7N9 infection. Serological inflammatory markers were higher in fatal cases compared to survivors. Acute respiratory distress syndrome (100%), respiratory failure (100%), co-infection with bacteria (60%), shock (50%) and congestive heart failure (50%) were the most common complications observed in fatal cases. The median time from onset of symptoms to antiviral therapy was 4.6 and 7.4 days in those who survived and those who died, respectively (p = 0.04). Viral HA, NA and MP nucleotide sequences of isolates from both study groups exhibited high molecular genetic homology.ConclusionsAge along with a history of smoking, chronic lung disease, immuno-suppressive disorders, chronic drug use and delayed Oseltamivir treatment are risk factors which might contribute to fatal outcome in human H7N9 infection.Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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