• Biol Res Nurs · Oct 2004

    Randomized Controlled Trial Clinical Trial

    The effect of early postoperative physical activity on tissue oxygen and wound healing.

    • JoAnne D Whitney and Sharon Parkman.
    • University of Washington School of Nursing, Seattle 98195, USA. joiewhit@u.washington.edu
    • Biol Res Nurs. 2004 Oct 1;6(2):79-89.

    BackgroundSupplemented postoperative activity was compared to standard activity for effects on wound healing, subcutaneous tissue perfusion, and oxygen (PscO2) following hip replacement (THR).Methods58 patients were randomized to standard post-THR activity (N = 27) or supplemental activity (N = 31) (arm and leg exercises, walking protocol). PscO2was measured with a microelectrode/tonometer system and perfusion determined by oxygen response. Healing was evaluated by (1) tissue cellularity, (2) mRNA for pro collagen, (3) hydroxyproline, and (4) DNA content obtained from a subcutaneous implant removed on the 7th postoperative day.ResultsActivity significantly increased DNA levels, but did not increase PscO2, perfusion, cellularity, or collagen measures.ConclusionsHealing measures were not improved with increased activity levels. However, activity did not reduce PscO2or wound healing. The majority of patients adhered to additional activity and tolerated the protocol well. Increased activity was associated with earlier discharge, suggesting other recovery-related benefits.Copyright 2004 Sage Publications

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