• Can J Anaesth · Oct 1999

    Randomized Controlled Trial Comparative Study Clinical Trial

    Ramosetron vs granisetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.

    • Y Fujii, Y Saitoh, H Tanaka, and H Toyooka.
    • Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.
    • Can J Anaesth. 1999 Oct 1;46(10):991-3.

    PurposeTo compare the efficacy of ramosetron with granisetron for the prevention of postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy.MethodsIn a randomized, double-blind study, 80 female inpatients received 3 mg granisetron or 0.3 mg ramosetron i.v. (n=40 of each) at the completion of surgery The standardized anesthetic included isoflurane and nitrous oxide in oxygen.ResultsComplete response, defined as no PONV, during the first 24 hr (0-24 hr) after anesthesia was 85% with granisetron and 93% with ramosetron, respectively (P=0.241); the corresponding incidence during the next 24 hr (24-48 hr) after anesthesia was 63% and 90% (P=0.004). No clinically important adverse events due to the study drug were observed in any of the groups.ConclusionRamosetron was more effective than granisetron for prevention of PONV during 0-48 hr after anesthesia for laparoscopic cholecystectomy.

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