• Rev Med Interne · Jun 2008

    Review

    [Rare thrombophilic states].

    • J Emmerich.
    • Inserm U765, médecine vasculaire - HTA, hôpital européen Georges-Pompidou, université Paris-Descartes, 20, rue Leblanc, 75908 Paris cedex 1, France. joseph.emmerich@egp.aphp.fr
    • Rev Med Interne. 2008 Jun 1;29(6):482-5.

    PurposeRare thrombophilic states are mostly associated with recurrent venous thrombosis or severe thrombosis such as neonatal purpura fulminans. We review here the various causes of rare thrombophilic states.Current Knowledge And Key PointsRare thrombophilic states associated with recurrent venous thrombosis include the following: antithrombin deficiencies, homozygous for protein C or protein S deficiency or compound heterozygous, double heterozygous for genetic thrombophilia and the rare thrombophilia due to auto-antibodies. Their frequency in patients with venous thromboembolism is below 2%.Future Prospects And ProjectsThese uncommon thrombophilic states require a treatment in a specialized department.

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