• Claire Roger, Ludovic Palmier, Benjamin Louart, Nicolas Molinari, Pierre-Geraud Claret, Jean-Emmanuel de la Coussaye, Jean-Yves Lefrant, and Laurent Muller.
• Department of anaesthesiology, emergency and critical care medicine, Nîmes university hospital, place du Pr.-Debré, 30029 Nîmes cedex 9, France. Electronic address: claire.roger@chu-nimes.fr.
• Anaesth Crit Care Pain Med. 2015 Aug 1; 34 (4): 231-7.

Aim Of The StudyIdentifying clinical, electrophysiological and biological predictors for 6-month neurological outcome in survivors at day 3 after cardiac arrest (CA) treated with therapeutic hypothermia (TH).MethodsWe conducted a retrospective cohort study of adults comatose after out-of hospital CA treated with TH. All data were collected from medical charts and laboratory files.ResultsBetween January 2010 and March 2013, among the 130 analysed CA survivors, 27 (21%) had a good neurological outcome at 6 months and 103 (79%) had a poor neurological outcome, including 98 deaths. The Glasgow coma score motor response (GCS-M), pupillary reflexes and Neuron Specific Enolase (NSE) were the three best predictors of neurological outcome (P<0.0001). The area under the Receiver Operating Characteristic curve for NSE was 0.92 [0.84-0.99].ConclusionNSE values, GCS-M scores and pupillary reflexes are the best predictors of poor 6-month outcome after out-of-hospital CA treated with TH. Of these, NSE values have the best-isolated prognostic performance when above 28.8μg/L.Copyright © 2015 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.

32 keywords...

hide…