• Tucker Tomlinson, Jack Chen, Vidyadhar Upasani, and Andrew Mahar.
• Orthopedic Biomechanics Research Center, Department of Orthopedics, Rady Children's Hospital San Diego, San Diego, CA 92123, USA.
• Spine. 2008 Sep 15;33(20):2127-33.

Study DesignIn vitro biomechanical investigation of lumbosacropelvic spinal instrumentation.ObjectiveDetermine whether unilateral iliac fixation, with or without an L6 to S1 interbody graft, provides equivalent biomechanical stability compared with bilateral iliac fixation.Summary Of Background DataRecent clinical evidence has shown improved clinical outcomes of unilateral iliac fixation compared with bilateral instrumentation that contradicts biomechanical data supporting bilateral instrumentation, although no specific investigation has compared unilateral versus bilateral instrumentation.MethodsSixteen porcine spines were instrumented with bilateral segmental pedicle screws from L1 to S1 and 5.5-mm titanium rods. Spines were randomized to either have an intact L6 to S1 disc space (n = 8/group) or a full discectomy and intervertebral cage at L6 to S1 (n = 8/group). Four reflective noncolinear markers were attached to both L6 and S1. Spines were tested with bilateral ilium, unilateral ilium, and sacrum-only fixation in flexion, extension, lateral bending, and axial torsion between +/-7.0 Nm. L6 to S1 range of motion (degrees) and mechanical stiffness (Nmm/degrees) were compared between groups with a 2-way analysis of variance (P < 0.05).ResultsNo significant differences were found in construct stiffness or L6 to S1 motion between unilateral or bilateral fixation for any test direction and both demonstrated significantly less L6 to S1 motion compared with sacrum-only fixation for all tests (all P values <0.005). Bilateral fixation was significantly stiffer than sacrum-only fixation in flexion and extension (P < 0.0001). The interbody cage significantly decreased construct stiffness in extension, lateral bending, and axial torsion (P < 0.002), and significantly increased L6 to S1 motion in torsion compared with an intact disc (P < 0.03).ConclusionThere were no biomechanical differences between bilateral and unilateral iliac screw fixation. Intervertebral cage with full discectomy was significantly less stiff than intact. This study provides biomechanical data to correlate with improved clinical outcomes using unilateral iliac screw fixation, and evidence contraindicating full discectomy with intervertebral cage placement.

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