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- Chun-Hui Bao, Peng Liu, Hui-Rong Liu, Lu-Yi Wu, Xiao-Ming Jin, Si-Yao Wang, Yin Shi, Jian-Ye Zhang, Xiao-Qing Zeng, Li-Li Ma, Wei Qin, Ji-Meng Zhao, Vince D Calhoun, Jie Tian, and Huan-Gan Wu.
- Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China Outpatient Department, Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA Department of Radiology, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, China The Mind Research Network, Albuquerque, NM, USA Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA.
- Pain. 2016 May 1; 157 (5): 1037-1044.
AbstractAbnormal pain processing in the central nervous system may be related to abdominal pain in patients with Crohn's disease (CD). The purpose of this study was to investigate changes in resting-state brain activity in patients with CD in remission and its relationship with the presence of abdominal pain. Twenty-five patients with CD and with abdominal pain, 25 patients with CD and without abdominal pain, and 32 healthy subjects were scanned using a 3.0-T functional magnetic resonance imaging scanner. Regional homogeneity (ReHo) was used to assess resting-state brain activity. Daily pain scores were collected 1 week before functional magnetic resonance imaging. We found that patients with abdominal pain exhibited lower ReHo values in the insula, middle cingulate cortex (MCC), and supplementary motor area and higher ReHo values in the temporal pole. In contrast, patients without abdominal pain exhibited lower ReHo values in the hippocampal/parahippocampal cortex and higher ReHo values in the dorsomedial prefrontal cortex (all P < 0.05, corrected). The ReHo values of the insula and MCC were significantly negatively correlated with daily pain scores for patients with abdominal pain (r = -0.53, P = 0.008 and r = -0.61, P = 0.002, respectively). These findings suggest that resting-state brain activities are different between remissive patients with CD with and without abdominal pain and that abnormal activities in insula and MCC are closely related to the severity of abdominal pain.
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