• Pediatric neurology · Sep 1992

    Vigabatrin in intractable childhood epilepsy: a retrospective study.

    • J M Gibbs, R E Appleton, and L Rosenbloom.
    • Department of Neurology, Royal Liverpool Children's Hospital, Alder Hey, England.
    • Pediatr. Neurol. 1992 Sep 1;8(5):338-40.

    AbstractThe effects of vigabatrin were studied over a 6-month period in 43 patients with intractable epilepsy. Children with complex partial seizures, with or without secondary generalization, responded best with more than one-half achieving a greater than 50% reduction; generalized tonic-clonic seizures also improved but there was no significant change in absence or myoclonic seizures. Four patients are seizure-free on monotherapy with vigabatrin. The drug was well tolerated with few side effects.

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