• Mark A Gilger, Renee S Spearman, Craig L Dietrich, Glen Spearman, Michael J Wilsey, and Mayssa N Zayat.
• Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas 77030-2399, USA.
• Gastrointest. Endosc. 2004 May 1;59(6):659-63.

BackgroundThe ideal sedation for children undergoing GI endoscopy remains elusive. After ketamine was introduced as a sedative agent in our GI procedure suite, improved sedation and reduced complications were observed. The aim of this study was to assess the safety and effectiveness of ketamine as a sedative agent for GI endoscopy in pediatric patients.MethodsA retrospective cohort study of 402 procedures (EGD, colonoscopy) was performed. Sedation-related complications were defined as hypoxia (oxygen saturation <95% by pulse oximetry), agitation, emergence reactions, stridor, laryngospasm, nausea, vomiting, aspiration, and muscle twitching, or any combination thereof. Sedation groups were defined as the following: Group I, midazolam and meperidine (n=192); Group II, midazolam, meperidine, and ketamine (n=82); and Group III, midazolam and ketamine (n=128).ResultsGroup 1 (midazolam and meperidine) had the highest frequency of complications, most commonly hypoxia. Group 3 (midazolam and ketamine) had the lowest rate of complications (p=0.001) and the highest rate of adequate sedation, although the difference was not significant (p=0.07).ConclusionsThe combination of midazolam and ketamine appears to provide safe and effective sedation for pediatric patients undergoing endoscopy.

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