• Michael Stoffel, Iris Wolf, Florian Ringel, Carsten Stüer, Horst Urbach, and Bernhard Meyer.
• Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
• J Neurosurg Spine. 2007 Apr 1;6(4):313-9.

ObjectThe aim of this study was to test the hypothesis that kyphoplasty is an effective treatment in painful osteoporotic vertebral fractures, even with involvement of the posterior cortical wall.MethodsBetween December 2001 and May 2004, 74 consecutive patients were treated with kyphoplasty for 118 painful osteoporotic compression (38%) or burst (62%) fractures. Additional decompression of the spinal canal was performed in six patients, internal fixation in three. Data were collected in a prospective observational design until May 2005. The preoperative workup included neuroimaging (plain x-ray films, densitometry, short tau inversion recovery magnetic resonance imaging, and computed tomography scanning) and clinical parameters (general and neurological examinations, visual analog scale [VAS], Karnofsky Performance Scale [KPS], and 36-Item Short Form Health Survey [SF]-36). At predefined time intervals (at discharge and 6 weeks and 3, 6, 12, and 24 months posttherapy) the patients were evaluated (x-ray films, neurological status, VAS, KPS, and SF-36). Kyphoplasty led to a significant reduction in kyphotic deformity (mean +/- standard error of the mean, sagittal index: preoperative 10 +/- 1 degrees, postoperative 5 +/- 1 degrees), and an improvement in pain (VAS: preoperative 70 +/- 3, postoperative 23 +/- 2), activity (KPS score: preoperative 51 +/- 3, postoperative 71 +/- 2), and mental and physical health (SF-36, mental status: preoperative 43, postoperative 58; SF-36, physical status: preoperative 24, postoperative 35). No secondary narrowing of the spinal canal by the retropulsed posterior wall was observed after the procedure. Clinical improvement was durable (mean follow up 15 +/- 1.1 months), although the VAS score secondarily increased slightly. All patients, who suffered from a compression-induced motor deficit, recovered completely during the follow-up interval. The main procedural complications consisted of one symptomatic extravertebral cement leakage (permanent monoparesis) requiring open revision, two nerve root contusions (transient radiculopathy), and one wound infection.ConclusionsKyphoplasty is effective in the treatment of painful osteoporotic vertebral compression and burst fractures, at least under medium-term conditions. The potential complication of procedure-related secondary narrowing of the spinal canal by the retropulsed posterior wall in burst fractures appears to be more of a theoretical than an actual risk.

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