• Hideaki Sakuramoto, Jesmin Subrina, Takeshi Unoki, Taro Mizutani, and Hiroko Komatsu.
• Intensive Care Unit, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan(1). Electronic address: gongehead@yahoo.co.jp.
• Intensive Crit Care Nurs. 2015 Aug 1; 31 (4): 250-7.

ObjectivesTo examine the hypothesis that severity of delirium in the intensive care unit (ICU) is positively associated with cognitive impairment at the time of hospital discharge.DesignA prospective cohort study.SettingAdult medical and surgical ICU of a tertiary-care teaching hospital in Japan in ICU patients who were enrolled and admitted for more than 48hours.MethodsSeverity of delirium was represented as a score of the Intensive Care Delirium Screening Checklist (ICDSC) during the patients' stay in the ICU under the assumption that higher ICDSC score indicated severe delirium. After discharge from the ICU, the patients were followed up for cognitive impairment using the Mini-Mental State Examination (MMSE).ResultsOf the 79 patients enrolled, 50 (63.3%) developed delirium during their stay in the ICU. Patients who developed delirium had higher rates of cognitive impairment (28.0% vs. 3.4%, p=0.03). After adjusting for covariates, the averaged ICDSC score during the ICU stay indicated a positive association between severity of delirium and cognitive impairment at the time of hospital discharge (adjusted odds ratio (OR) 1.6; 95% confidential interval (CI), 1.02-2.54; p=0.041).ConclusionsOur findings indicate that severity of delirium during ICU stay may be associated with cognitive impairment at the time of discharge from the hospital in ICU survivors.Copyright © 2015 Elsevier Ltd. All rights reserved.

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