• Blood purification · Jan 2013

    Myoglobin removal using high-volume high-flux hemofiltration in patients with oliguric acute kidney injury.

    • Nelio Guzman, Amber S Podoll, Cynthia S Bell, and Kevin W Finkel.
    • Division of Renal Diseases and Hypertension, Division of Pediatric Nephrology, Departments of Internal Medicine and Pediatrics, UT Health Science Center at Houston, Medical School, Houston, Tex., USA.
    • Blood Purif. 2013 Jan 1;36(2):107-11.

    BackgroundRhabdomyolysis can cause acute kidney injury (AKI). It remains controversial whether or not myoglobin can be removed from the circulation with extracorporeal therapy and decrease the incidence of AKI. Therefore, we examined myoglobin removal in a series of 11 patients with oliguric AKI treated with high-volume hemofiltration.MethodsPatients received prefilter hemofiltration using a polysulphone filter with a molecular size cutoff of 65 kDa and a surface area of 1.7 m(2). Sieving coefficients and myoglobin clearances were calculated at 6, 12, and 24 h after the start of hemofiltration.ResultsThe mean sieving coefficient was 0.158, and the mean myoglobin clearance was 8.7 ml/min.ConclusionDespite the use of high-volume hemofiltration, the removal of myoglobin was negligible. In patients with normal renal function, the anticipated amount of extracorporeal removal would not significantly impact renal exposure to myoglobin.© 2013 S. Karger AG, Basel.

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