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Int J Obstet Anesth · Jan 2005
Case ReportsAnaesthetic management during labour of a manifesting carrier of Duchenne muscular dystrophy.
- M K Molyneux.
- Department of Anaesthesia, Bristol Royal Infirmary, Bristol BS2 8HW, UK. matmol@doctors.net.uk
- Int J Obstet Anesth. 2005 Jan 1;14(1):58-61.
AbstractWe describe the peripartum anaesthetic management of a 36-year-old woman who was a manifesting carrier of Duchenne muscular dystrophy. Duchenne muscular dystrophy is an X-linked recessive disorder affecting young males associated with severe complications during anaesthesia if depolarising neuromuscular blocking drugs and volatile agents are used. A manifesting carrier is a heterozygous female who demonstrates the disease in a milder form than in males. This probably occurs because of skewed X-inactivation. We planned to establish regional anaesthesia should an operation be necessary during labour or delivery and to use propofol total intravenous anaesthesia and rocuronium if general anaesthesia became unavoidable. At 37 weeks, the woman went into spontaneous labour, but fetal distress necessitated caesarean section for which combined spinal-epidural anaesthesia was used.
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