• M Nakao, S Yamanaka, A Harada, and I Onji.
• Department of Anesthesiology and Pain Control, Chuden Hospital of Chugoku Electric Power Company Inc., Hiroshima.
• Masui. 2000 Jul 1;49(7):802-5.

AbstractWe found fine cracks in a three-way stopcock after continuous infusion of propofol (Diprivan, Astra-Zeneca, UK). In this paper the possible mechanism was investigated. At first we checked various three-way stopcocks of various manufactures, such as JMS, Terumo, Nipro and Top. All of them were made with polycarbonate. Fine cracks were observed in all stopcocks after 6 hours of liquid contact with propofol between the three-way stopcock and male connector. Based on the mechanical stretch tests of polycarbonate plastic strips with saline, 10% fat emulsion (Intralipid, Otsuka, Japan), or 1% propofol in 10% fat emulsion (Diprivan), significantly greater cracks were observed in both fat group and propofol group, compared with the saline group. But there was no significant difference in cracks between fat and propofol groups. The size of crack increased in a time and strength dependent manner. We conclude that the cause of cracks in three-way stopcock is fat emulsion as a vehicle of propofol not propofol itself.

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