• Kirsti L Vik, Pål Romundstad, David Carslake, Davey Smith George G MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., and Tom I L Nilsen.
• Department of Public Health, Norwegian University of Science and Technology, Norway Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU), Norway kirsti.lund.vik@ntnu.no.
• Eur J Prev Cardiol. 2016 Jan 1; 23 (2): 145-53.

BackgroundCardiovascular risk factors are known to be associated between parents and offspring. However, whether these associations are reflected in increased offspring mortality has not been extensively studied.DesignThis was a family study of 32,536 father-offspring and 39,614 mother-offspring pairs who participated in the HUNT Study, Norway.MethodsAdjusted hazard ratios (HRs) for offspring total and cardiovascular mortality associated with parental levels of cardiovascular disease risk factors were estimated using Cox regression.Results And ConclusionsFathers' and mothers' reporting of cardiovascular disease (HRs: 1.18; 95% CI 1.04-1.32 and 1.20; 1.07-1.35, respectively), diabetes (HRs: 1.22; 95% CI 1.00-1.49 and 1.21; 1.05-1.40, respectively), and current smoking (HRs: 1.21; 95% CI 1.08-1.36 and 1.30; 1.15-1.47, respectively) was associated with total mortality in offspring. An inverse association was found with maternal height (HR: 0.95; 95% CI 0.91-0.99), and a suggestive inverse association with paternal height (HR: 0.98; 95% CI 0.93-1.03). Relations with offspring cardiovascular mortality were less clear and consistent. Offspring whose parents both had a risk factor did not seem to have higher mortality than would be expected from the independent effects of each parent.© The European Society of Cardiology 2014.

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