• Carlos Fernando Ronchi, Ana Lucia Anjos Ferreira, Fabio Joly Campos, Cilmery Suemi Kurokawa, Mario Ferreira Carpi, Marcos Aurélio Moraes, Rossano Cesar Bonatto, Kyung-Jin Yeum, and Jose Roberto Fioretto.
• Department of Pediatrics, Botucatu Medical School - Sao Paulo State University (UNESP), Botucatu, SP, Brazil; Jean Mayer USDA - Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA; Department of Health Sciences - Universidade do Sagrado Coração (USC), Bauru, SP, Brazil. Electronic address: ronchi.carlos@yahoo.com.
• Respir Physiol Neurobiol. 2014 Jan 1;190:118-23.

AbstractTo compare conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV), with/without inhaled nitric oxide (iNO), for oxygenation, inflammation, antioxidant/oxidative stress status, and DNA damage in a model of acute lung injury (ALI). Lung injury was induced by tracheal infusion of warm saline. Rabbits were ventilated at [Formula: see text] 1.0 and randomly assigned to one of five groups. Overall antioxidant defense/oxidative stress was assessed by total antioxidant performance assay, and DNA damage by comet assay. Ventilatory and hemodynamic parameters were recorded every 30min for 4h. ALI groups showed worse oxygenation than controls after lung injury. After 4h of mechanical ventilation, HFOV groups presented significant improvements in oxygenation. HFOV with and without iNO, and CMV with iNO showed significantly increased antioxidant defense and reduced DNA damage than CMV without iNO. Inhaled nitric oxide did not beneficially affect HFOV in relation to antioxidant defense/oxidative stress and pulmonary DNA damage. Overall, lung injury was reduced using HFOV or CMV with iNO.Copyright © 2013 Elsevier B.V. All rights reserved.

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