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J Invest Allerg Clin · Jan 2005
Case ReportsHydrochlorothiazide-induced acute non-cardiogenic pulmonary edema.
- P M Gamboa, V Achotegui, J Irigoyen, J Pérez-Asenjo, J Merino, and M L Sanz.
- Servicio de Alergología, Hospital de Basurto, Bilbao, Spain. pgamboa@hbas.osakidetza.net
- J Invest Allerg Clin. 2005 Jan 1;15(4):299-301.
AbstractWe report the case of a 64 year-old male with non cardiogenic pulmonary edema episodes after oral administration of 12.5 mg of hydrochlorothiazide. In vitro immunologic study with basophil activation test and late cellular activation study (CD69 and production of interferon gamma) with chlorothiazide were performed, and no activation was observed. As a consequence, like in previous cases published, the pathogenic mechanism remains unknown, and it probably is an idiosyncratic reaction.
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