• Am J Geriatr Psychiatry · Mar 2002

    Randomized Controlled Trial Clinical Trial

    Ondansetron in the treatment of cognitive decline in Alzheimer dementia.

    • Maurice Dysken, Michael Kuskowski, Susan Love, and Ondansetron Study Group.
    • Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA.
    • Am J Geriatr Psychiatry. 2002 Mar 1;10(2):212-5.

    AbstractThe authors performed a multicenter, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of ondansetron (20 microg/day and 100 microg/ day) in treating cognitive decline in 185 patients with Alzheimer disease. Although ondansetron was well tolerated without any serious drug-related side effects, the study failed to demonstrate any significant cognitive improvement.

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