• Int J Obstet Anesth · Jan 2007

    Review Case Reports

    Use of recombinant activated factor VII in massive obstetric haemorrhage.

    • J Haynes, M Laffan, and F Plaat.
    • Obstetric Anaesthesia Department, Queen Charlotte's and Chelsea Hospital, and Department of Haematology, Hammersmith Hospital, London, UK.
    • Int J Obstet Anesth. 2007 Jan 1;16(1):40-9.

    AbstractMassive obstetric haemorrhage is a life-threatening emergency that remains a major cause of maternal mortality. Conventional management is aimed at optimising uterine tone, replacing circulating volume and blood products, and surgery to achieve haemostasis. Recently there have been numerous reports of the (unlicensed) use of recombinant activated factor VII in the management of major obstetric haemorrhage. We report our experience of using it in the treatment of major post-partum haemorrhage in four previously healthy parturients. The published reports of recombinant activated factor VII use in post-partum haemorrhage (unrelated to pre-existing coagulopathies) are compared.

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