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Neurorehabil Neural Repair · Jan 2000
ReviewNeurotrophic factors and gene therapy in spinal cord injury.
- S Lacroix and M H Tuszynski.
- Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0626, USA.
- Neurorehabil Neural Repair. 2000 Jan 1;14(4):265-75.
AbstractAlthough it was once thought that the central nervous system (CNS) of mammals was incapable of substantial recovery from injury, it is now clear that the adult CNS remains responsive to various substances that can promote cell survival and stimulate axonal growth. Among these substances are growth factors, including the neurotrophins and cytokines, and growth-supportive cells such as Schwann cells, olfactory ensheathing glia, and stem cells. We review the effects of these substances on promoting axonal growth after spinal cord injury, placing particular emphasis on the genetic delivery of nervous system growth factors to specific sites of injury as a means of promoting axonal growth and, in limited instances, functional recovery.
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