• Mark Quigg, John Rolston, and Nicholas M Barbaro.
• Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA. quigg@virginia.edu
• Epilepsia. 2012 Jan 1;53(1):7-15.

AbstractStereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway.Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.

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