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- B H Mavromatis and C M Kessler.
- Division of Hematology/Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA. mavromab@gunet.georgetown.edu
- J. Clin. Pathol. 2001 Sep 1;54(9):664-8.
AbstractPulmonary embolism is a common, yet often unsuspected and unrecognised disease associated with a high mortality. New, objective, "user friendly" and cost effective diagnostic strategies are being explored. D-dimers, the fibrinolytic degradation products of crosslinked fibrin, have emerged as the most useful of the procoagulant activity and ongoing fibrinolysis markers. D-dimer measurements are very sensitive in excluding a diagnosis of pulmonary embolism in the setting of normal values, a low clinical suspicion, and non-diagnostic lung scans. Several assays have been developed and are reviewed.
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