• Pharmacotherapy · Dec 2002

    Review

    Pharmacology, clinical efficacy, and safety of drotrecogin alfa (activated).

    • Maria I Rudis and Douglas N Fish.
    • Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA. rudis@hsc.usc.edu
    • Pharmacotherapy. 2002 Dec 1;22(12 Pt 2):182S-195S.

    AbstractThe protein C pathway, which plays an important role in maintaining normal hemostasis and is a critical link between the inflammatory and procoagulant host responses to infection, is involved in modulating the coagulation and inflammation associated with severe sepsis. Recombinant human activated protein C (APC), or drotrecogin alfa (activated), shares the intrinsic pharmacologic activity of endogenous APC. In the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial, drotrecogin alfa (activated) decreased absolute mortality by 6% and relative risk of mortality by 19% compared with placebo. Drotrecogin alfa (activated) is an important advancement in the treatment of adult patients with severe sepsis.

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