• Jpen Parenter Enter · Mar 1996

    Randomized Controlled Trial Clinical Trial

    Glucose response to discontinuation of parenteral nutrition in patients less than 3 years of age.

    • K Bendorf, C A Friesen, and C C Roberts.
    • Section of Gastroenterology and Nutrition Support, Children's Mercy Hospital, Kansas City, Missouri 64108, USA.
    • Jpen Parenter Enter. 1996 Mar 1;20(2):120-2.

    BackgroundThe effects of abrupt discontinuation and tapering of total parenteral nutrition (TPN) on glucose concentration were compared in patients < 3 years of age.MethodsSerial glucose concentrations were measured over 120 minutes after abrupt discontinuation as compared with tapering (decreasing infusion rate by 50% for 1 hour before discontinuation). Serial insulin concentrations were measured after abrupt discontinuation.ResultsThere was a significantly greater decrease in glucose concentration from baseline at 30 minutes after abrupt discontinuation as compared with tapering. Fifty-five percent (6/11) of the patients developed hypoglycemia (glucose concentration < 40 mg/dL) after abrupt discontinuation. Age, glucose infusion rate, and serum insulin concentrations were not predictive of the development of hypoglycemia. The tapering regimen did not prevent hypoglycemia, which developed in 20% (2/10).ConclusionThe high incidence of hypoglycemia after TPN discontinuation in children < 3 years of age requires monitoring of serum glucose concentration when initiating intermittent TPN until tolerance is documented.

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