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Expert Rev Anticancer Ther · Feb 2012
ReviewTherapeutic potential of irreversible electroporation in sarcoma.
- Zhe Yu, Xudong Zhang, Pengcheng Ren, Minghua Zhang, and Jixian Qian.
- Center of Orthopedic Surgery, Orthopedics Oncology Institute of Chinese PLA, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710038, PR China. yuzhe780519@yahoo.com.cn
- Expert Rev Anticancer Ther. 2012 Feb 1;12(2):177-84.
AbstractIrreversible electroporation is a newly developed nonthermal tissue ablation technique in which certain short-duration electrical fields are used to permanently permeabilize the cell membrane to disrupt cellular homeostasis. This disruption of cellular homeostasis initiates apoptosis, which leads to permanent cell death. Sarcomas are generally divided into soft-tissue and bone sarcomas based on their different mesenchymal origins and anatomical locations. Each of these sarcomas present in different ways, exhibit different behaviors and prognoses, and present unique therapeutic challenges. In this article, a series of recently conducted irreversible electroporation treatment for sarcomas based on local nonthermal ablation are summarized, and the therapeutic potential of this newly developed technique is assessed.
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