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Am. J. Trop. Med. Hyg. · Oct 2012
Case ReportsTreatment of granulomatous amoebic encephalitis with voriconazole and miltefosine in an immunocompetent soldier.
- Duncan Webster, Imran Umar, Imram Umar, George Kolyvas, Juan Bilbao, Marie-Christine Guiot, Kevin Duplisea, Yvonne Qvarnstrom, and Govinda S Visvesvara.
- Department of Internal Medicine, Saint John Regional Hospital, Saint John, New Brunswick, Canada. Duncan.Webster@HorizonNB.ca
- Am. J. Trop. Med. Hyg. 2012 Oct 1;87(4):715-8.
AbstractA 38-year-old male immunocompetent soldier developed generalized seizures. He underwent surgical debulking and a progressive demyelinating pseudotumor was identified. Serology and molecular testing confirmed a diagnosis of granulomatous amoebic encephalitis caused by Acanthamoeba sp. in this immunocompetent male. The patient was treated with oral voriconazole and miltefosine with Acanthamoeba titers returning to control levels and serial imaging demonstrating resolution of the residual lesion.
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