• Expert Rev Anti Infect Ther · Oct 2008

    Review

    Extensively drug-resistant tuberculosis: new strains, new challenges.

    • Ritu Banerjee, Gisela F Schecter, Jennifer Flood, and Travis C Porco.
    • Division of Infectious Disease, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143-0136, USA. banerjeer@peds.ucsf.edu
    • Expert Rev Anti Infect Ther. 2008 Oct 1;6(5):713-24.

    AbstractExtensively drug-resistant (XDR)-TB, defined as TB with resistance to at least isoniazid, rifampin, a fluoroquinolone and either amikacin, kanamycin or capreomycin, is a stark setback for global TB control. Overburdened public-health systems with inadequate resources for case detection and management and high HIV coinfection rates in many regions have contributed to the emergence of XDR-TB. Patients with XDR-TB have poor outcomes, prolonged infectious periods and limited treatment options. To prevent an epidemic of untreatable XDR-TB, improvements in XDR-TB surveillance, increased laboratory capacity for rapid detection of drug-resistant strains, better infection control and the development of new therapeutics are urgently needed.

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