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Case Reports
Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease.
- Volker Hesselmann, Bettina Sorger, Ralf Girnus, Kathrin Lasek, Mohammad Maarouf, Christoph Wedekind, Jürgen Bunke, Oliver Schulte, Barbara Krug, Klaus Lackner, and Volker Sturm.
- Department of Radiology, University of Cologne, Joseph-Stelzmann-Strasse 9, 50924 Cologne, Germany. Volker.Hesselmann@uni-koeln.de
- Eur Radiol. 2004 Apr 1;14(4):686-90.
AbstractThis article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.
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