• Southern medical journal · Sep 1997

    Review Case Reports

    Methemoglobinemia caused by benzocaine topical spray.

    • H A Cooper.
    • Department of Medicine, Duke University Medical Center, Durham, NC, USA.
    • South. Med. J. 1997 Sep 1;90(9):946-8.

    AbstractAcute methemoglobinemia is a medical emergency that can rapidly become fatal. A substantial number of drugs, including topical preparations, can precipitate this condition. I report a rare example of severe, acute methemoglobinemia caused by oropharyngeal anesthesia with topical benzocaine spray for orogastric intubation. The pathophysiology, diagnosis, and treatment of methemoglobinemia are reviewed briefly.

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