• Int. J. Dermatol. · Nov 2008

    Nail changes in pemphigus vulgaris.

    • Mohammadali Habibi, Hossein Mortazavi, Shervin Shadianloo, Kamran Balighi, S Zahra Ghodsi, Maryam Daneshpazhooh, Mahin Valikhani, Akhgar Ghassabian, Aydin H Pooli, and Cheyda Chams-Davatchi.
    • Department of Dermatology, Pemphigus Research Unit, Razi Hospital, Tehran University for Medical Sciences, Tehran, Iran.
    • Int. J. Dermatol. 2008 Nov 1;47(11):1141-4.

    BackgroundThe frequency and types of nail changes in pemphigus vulgaris (PV) are unclear. Aim To determine the frequency and types of nail changes, and their correlation with the number of skin and periungual bullae.MethodsSeventy-nine patients with PV, including 59 new patients and 20 patients in relapse, were entered into the study. Microscopic examination in potassium hydroxide and culture for fungus were performed on all clinically abnormal nails.ResultsTwenty-five (31.6%) of 79 patients showed nail changes, with paronychia (n = 8) and onychomadesis (n = 6) being the most common. One patient in relapse had onychomycosis. The frequency of nail changes in fingers affected by periungual bullae was significantly higher than in other fingers (P < 0.05). The number of nail changes was higher in patients with a larger number of skin bullae and in those with a longer duration of disease (P < 0.05).ConclusionsNail changes in PV are common and related to the number of skin bullae and the presence of periungual bullae.

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