-
- Wenya Linda Bi, Malak Abedalthagafi, Peleg Horowitz, Pankaj K Agarwalla, Yu Mei, Ayal A Aizer, Ryan Brewster, Gavin P Dunn, Ossama Al-Mefty, Brian M Alexander, Sandro Santagata, Rameen Beroukhim, and Ian F Dunn.
- Department of Neurosurgery, Brigham and Women's Hospital;
- J. Neurosurg. 2016 Sep 1; 125 (3): 525-35.
AbstractMeningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.
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