• Bernd Saugel, Julia Jakobus, Wolfgang Huber, Dieter Hoffmann, Konstantin Holzapfel, Ulrike Protzer, Roland M Schmid, and Andreas Umgelter.
• II. Medizinische Klinik und Poliklinik. Klinikum rechts der Isar der Technischen Universität München, 81675 München, Germany. Electronic address: bernd.saugel@gmx.de.
• J Crit Care. 2016 Apr 1; 32: 138-44.

PurposeIn intensive care unit (ICU) patients in whom bronchoalveolar lavage fluid (BALF) was analyzed for suspected infectious pulmonary disease, we investigated the association of herpes simplex virus (HSV) in the BALF with lung injury and patient outcome.Materials And MethodsIn this retrospective cohort study, we included 201 patients treated in a medical ICU of a German university hospital in whom BALF samples were analyzed for the presence of HSV using quantitative polymerase chain reaction analysis.ResultsEighty-seven patients (43%) were HSV-negative, and 114 patients (57%) were HSV-positive. At the day of BALF sampling (day 0), there was no clinically relevant (or statistically significant) difference in the Modified Clinical Pulmonary Infection Score, Lung Injury Score, and single indicator transpulmonary thermodilution-derived extravascular lung water index and pulmonary vascular permeability index between HSV-negative patients and HSV-positive patients or HSV-positive patients with greater than 10(5) HSV copies/mL. The ICU and hospital length of stay was statistically significantly longer in HSV-positive patients compared with HSV-negative patients. Intensive care unit and hospital mortality was not statistically significantly different between the groups.ConclusionsWe did not find a clinically relevant or statistically significant association of HSV in the BALF of medical ICU patients with lung injury or with ICU and hospital mortality.Copyright © 2015 Elsevier Inc. All rights reserved.

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