• Thomas H Mallory, Adolph V Lombardi, Robert A Fada, Kathleen L Dodds, and Joanne B Adams.
• Joint Implant Surgeons, Inc, Columbus, Ohio 43215, USA. MalloryTH@ortholink.net
• J Arthroplasty. 2002 Jun 1;17(4 Suppl 1):129-33.

AbstractScheduled preoperative and postoperative analgesia should be offered in a multimodal management model. By a combined drug synergy effect, the central nervous system, afferent pathways, and peripheral wound site are modified collectively. In an ongoing effort to improve perioperative pain management, we retrospectively compared the results of a previously reported pain management protocol with 2 more recent groups of patients managed with modified pain protocols. In the earlier control protocol, epidural anesthesia was discontinued on arrival to the postanesthesia care unit, and regularly scheduled oral opioids and intravenous hydromorphone for breakthrough pain were initiated. The first more recent group used epidural anesthesia, and the second group used spinal anesthesia. Both protocols featured the use of cyclooxygenase-2-inhibiting anti-inflammatory medication administered for 2 weeks preoperatively and continued for 10 days postoperatively and patient-controlled analgesia for 24 hours followed by scheduled oral opioids.Copyright 2002, Elsevier Science (USA).

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