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- Philippe Horvath and Rodolphe Barrangou.
- DuPont Nutrition and Health, Dangé-Saint-Romain, 86220, France. philippe.horvath@dupont.com
- Cell Res. 2013 Jun 1;23(6):733-4.
AbstractTwo recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.
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