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Expert Opin Investig Drugs · Sep 2012
EditorialPregabalin in clinical psychiatry and addiction: pros and cons.
- Giovanni Martinotti.
- Expert Opin Investig Drugs. 2012 Sep 1;21(9):1243-5.
AbstractPregabalin acts as a presynaptic modulator of excitatory neurotransmitter release, binding to the α²-δ subunit protein of voltage-gated calcium channels. Pregabalin use is becoming widespread in the psychiatric scenario. Data are encouraging, with some good evidence for efficacy in anxious spectrum, benzodiazepine abuse/dependence, and alcoholism. The abuse potential, however, is an issue that should be taken into account, mostly in subjects at risk for developing substance/alcohol misuse.
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