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Journal of neurotrauma · Sep 1997
ReviewIndomethacin in the management of elevated intracranial pressure: a review.
- M R Harrigan, S Tuteja, and B L Neudeck.
- Department of Surgery, University of Michigan Medical Center, and College of Pharmacy, Ann Arbor, USA.
- J. Neurotrauma. 1997 Sep 1;14(9):637-50.
AbstractElevated intracranial pressure occurs frequently in patients with severe head injury. A number of studies in recent years suggest that indomethacin may be useful in the management of elevated intracranial pressure. Indomethacin acts primarily by reducing cerebral blood flow and decreasing cerebral edema following head injury. This review summarizes the basic and clinical studies of the effects of indomethacin on cerebral blood flow, brain edema, and intracranial pressure. The pharmacology of indomethacin, and issues for future investigation in the use of indomethacin in severe head injury, are discussed.
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