• Epilepsy research · Mar 1991

    Efficacy and safety evaluation of loreclezole as add-on treatment in therapy-resistant epilepsy patients.

    • T Rentmeester and J Hulsman.
    • Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands.
    • Epilepsy Res. 1991 Mar 1;8(2):166-9.

    AbstractThirteen drug-resistant epilepsy patients received loreclezole as add-on therapy. The trial lasted 6 months. Loreclezole was dosed to reach a target plasma concentration between 1 and 3 mg/l. The seizure frequency in the total group decreased by 23%. A reduction of 50% or more was observed in four patients. These effects are most likely related to loreclezole, as doses and plasma levels of the associated anti-epileptic drugs remained unchanged during the study. Loreclezole was tolerated well and no changes in haematological or biochemical parameters were observed.

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