• Ike Njere, Saidul Islam, Deborah Parish, Jauro Kuna, and Alireza S Keshtgar.
• Department of Pediatric Surgery, University Hospital Lewisham, National Health Service Trust, SE13 6LH London, UK.
• J. Pediatr. Surg. 2011 May 1;46(5):946-50.

Background/PurposePeripherally inserted central venous catheters (PICCs) are commonly used for neonatal vascular access. The aim of this study was to look at PICC line complication rates and possible predictors of PICC infection in a neonatal intensive care unit.MethodThis was a prospective study of 226 neonates who had PICCs on our neonatal intensive care unit between January 2006 and June 2009. Complete data was available on 218 neonates who had 294 PICC lines. Criteria for catheter-related sepsis was positive blood cultures (peripheral/central) and/or a positive catheter tip culture after removal in the presence of a clinical suspicion of line sepsis.ResultsOf 218 neonates, 132 (169 lines) were medical, and 86 (125 lines) were surgical. Our PICC line infection rate was 17 infections per 1000 catheter-days. Surgical neonates had infection rates of 24.8% compared with 18.3% of medical neonates (P < .18). The odds ratio for a PICC infection was 3.1 (95% confidence interval, 1.64-5.87) if the catheter was in situ for 9 days or more, P < .01. Coagulase-negative staphylococcus was isolated from 55 (89%) of 62 blood cultures.ConclusionsOur PICC infection rate was 17 per 1000 catheter-days. The length of catheter stay was the only predictor of PICC infection.Copyright © 2011 Elsevier Inc. All rights reserved.

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