• Pain · Feb 2016

    Human surrogate models of neuropathic pain: validity and limitations.

    • Andreas Binder.
    • Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany.
    • Pain. 2016 Feb 1; 157 Suppl 1: S48-52.

    AbstractHuman surrogate models of neuropathic pain in healthy subjects are used to study symptoms, signs, and the hypothesized underlying mechanisms. Although different models are available, different spontaneous and evoked symptoms and signs are inducible; 2 key questions need to be answered: are human surrogate models conceptually valid, ie, do they share the sensory phenotype of neuropathic pain states, and are they sufficiently reliable to allow consistent translational research?

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