• Blood Coagul. Fibrinolysis · Oct 2008

    Case Reports

    Prophylaxis with recombinant-activated factor VII (rFVIIa) for minimally invasive surgery in a patient with congenital factor VII deficiency: a case report with a single-low dose of rFVIIa.

    • Ali Abbas Yilmaz, Saban Yalcin, Hacer Serdaroglu, Murat Sonmezer, and Asuman Uysalel.
    • Department of Anesthesiology and Intensive Care, Ankara University Medical Faculty, Cayyolu, Ankara, Turkey. draliabbas@yahoo.com
    • Blood Coagul. Fibrinolysis. 2008 Oct 1;19(7):693-5.

    AbstractCongenital factor VII deficiency is a rare autosomal-recessive disorder and surgery in patients with factor VII deficiency has been reported to be endangered by intraoperative or postoperative bleeding, unless a replacement therapy is used. In this paper, we report a successful prophylaxis with single and low dose rFVIIa (12.5 microg kg(-1)) in a 22-year-old homozygote factor VII deficient patient who underwent laparoscopic gynecologic surgery. Minimally invasive surgeries, such as laparoscopic surgery, could be safely performed in patients with congenital factor VII using single and low dose rFVIIa combined with vigilant clinical observation and laboratory examination.

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