• François Harel, André Denault, Quam Ngo, Jocelyn Dupuis, and Paul Khairy.
• Department of Nuclear Medicine, Université de Montréal, Montreal, Quebec, Canada H1T 1C8. francois_harel@hotmail.com
• J Clin Monit Comput. 2008 Feb 1;22(1):37-43.

BackgroundNon-invasive evaluation of peripheral perfusion may be useful in many contexts including peri-operative monitoring. We validated a novel non-invasive spectroscopy technique to assess peripheral perfusion. This method, which is based on the measurement of tissue saturation variations after an ischemic period, was compared to strain gauge plethysmography and radionuclide plethysmography. The technique uses near-infrared spectroscopy (NIRS) to determine the rate of change of forearm tissue saturation during reactive hyperemia.MethodsIn a prospective crossover study, 25 subjects were simultaneously evaluated with NIRS and strain gauge plethysmography. Six baseline flow measurements were performed to assess the reproducibility of each method. Twenty-seven serial measurements were then made to evaluate flow variation during forearm reactive hyperemia.ResultsStrain gauge and NIRS methods showed excellent reproducibility with intra-class correlation coefficients of 0.96 and 0.93, respectively.ConclusionThe NIRS technique appears well suited for the non-invasive evaluation of limb perfusion.

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