• Joyce T Au, T Peter Kingham, Kyonghwa Jun, Dana Haddad, Sepideh Gholami, Kelly Mojica, Sebastien Monette, Paula Ezell, and Yuman Fong.
• Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
• Surgery. 2013 Jun 1;153(6):787-93.

BackgroundIrreversible electroporation (IRE) is a novel ablation technique that induces permanent membrane permeability and cell death. We are interested in ultrasound B-mode and elastography to monitor IRE ablation in the liver.MethodsYorkshire pigs underwent IRE ablation of the liver and were imaged with ultrasound B-mode and elastography. Histologic evaluation of cell death by triphenyltetrazolium chloride and hematoxylin and eosin staining was performed.ResultsElastography showed that liver ablated by IRE exhibited increased tissue stiffness with a peak strain ratio of 2.22. The IRE lesion had a discrete border without bubble artifact, and the lesion size significantly correlated with area of cell death on histology. IRE ablation was unaffected by presence of large blood vessels or bile ducts.ConclusionIRE ablation led to increased tissue stiffness that was detectable by elastography and indicative of cell death. Elastography may complement B-mode ultrasonography to monitor IRE ablation of the liver.Copyright © 2013 Mosby, Inc. All rights reserved.

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