• Ozlem Köksal, Fatma Ozdemir, Betül Cam Etöz, Naciye Işbil Büyükcoşkun, and Deniz Sığırlı.
• Department of Emergency Medicine, Uludağ University Faculty of Medicine, Bursa, Turkey. koksalozlem@gmail.com
• Ulus Travma Acil Cer. 2011 May 1;17(3):199-204.

BackgroundIn this study, the hemostatic efficacy of Celox® in rats under hypothermia or warfarin treatment was investigated.MethodsA total of forty-eight Sprague-Dawley female rats weighing 200-350 g were used in the study. Six experimental study groups were designed, as follows: Group 1: Normothermia + compression; Group 2: normothermia + Celox®; Group 3: hypothermia + compression; Group 4: hypothermia + Celox®; Group 5: normothermia + warfarin + compression; and Group 6: normothermia + warfarin + Celox®.ResultsCelox® provided effective hemorrhage control in all three tested groups. There was a statistically significant difference between compression and Celox® implementation in all groups in terms of hemostasis (p-values for the normothermia, hypothermia and warfarin groups were p<0.05, p<0.01 and p<0.01, respectively). Furthermore, the compression numbers were significantly lower in all of the groups that received Celox ® than in those in which compression alone was applied (p-values for the normothermia, hypothermia and warfarin groups were p<0.01, p<0.01 and p<0.001, respectively).ConclusionCelox® provides effective hemorrhage control under conditions of normothermia, hypothermia and use of the oral anticoagulant agent warfarin.

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