• Ediz Altınlı, Aziz Sümer, Neşet Köksal, Ender Onur, Serkan Senger, Ersan Eroğlu, Atilla Celik, and Gülistan Gümrükçü.
• Department of General Surgery Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
• Ulus Travma Acil Cer. 2011 Sep 1;17(5):377-82.

BackgroundThe aim of this study was to investigate the impact of oxidized generated cellulose, polyethylene glycol and hylan G-F 20 on adhesion formation, fibrosis and inflammation after repair of abdominal wall defect with polypropylene mesh in an animal model.MethodsForty rats were divided into four groups and abdominal wall defect was established. The defect was repaired with polypropylene mesh alone (control group), polypropylene mesh and hylan G-F 20 as adhesion barrier, polypropylene mesh and oxidized generated cellulose as adhesion barrier, or polypropylene mesh and polyethylene glycol as adhesion barrier in Groups I, II, III, and IV, respectively. Rats were sacrificed on the 14th day in all groups.ResultsA comparison of the groups in terms of macroscopic adhesion scores revealed statistically significant differences between the groups using an adhesion barrier and the control group. Severe fibroblast proliferation was seen in the control group and mild fibroblast proliferation was seen in polyethylene glycol group.ConclusionPolyethylene glycol is an effective adhesion prevention barrier. Laparoscopic surgery has become the standard method in most of the surgical field. With its laparoscopic apparatus, polyethylene glycol allows easy application on the damaged surface.

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