• Int J Gen Med · Jan 2010

    Update on transfusion solutions during surgery: review of hydroxyethyl starches 130/0.4.

    • Ornella Piazza, Giuliana Scarpati, and Rosalba Tufano.
    • Anaesthesia and Intensive Care, University of Naples Federico II, School of Medicine, Naples, Italy. orpiazza@unina.it
    • Int J Gen Med. 2010 Jan 1;3:287-95.

    ObjectivesRestoration of circulation is crucial in the surgical patient management. Colloids and crystalloids are widely used for blood volume therapy. We reviewed recent trials to evaluate efficacy and safety of hydroxyethyl starch (HES) 130/0.4 during surgery.Material And MethodsA subjective, not systematic, review of literature was performed. Papers were searched to answer questions about efficacy of HES, its impact on coagulation and inflammation and its effects on pulmonary mechanics and renal function.ConclusionsHES 130/0.4 is effective for volume therapy and is less expensive than human albumin. Its effects on coagulation and renal function are manageable; it may ameliorate pulmonary permeability and reduce inflammation.

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