• Int J Pharm · Jul 2011

    Evaluation of sugammadex self-association.

    • Sergey V Kurkov, Martin Messner, Marjoleine Lucassen, Diels J van den Dobbelsteen, John den Engelsman, and Thorsteinn Loftsson.
    • Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland.
    • Int J Pharm. 2011 Jul 15;413(1-2):134-9.

    AbstractSugammadex, a thiolated γCD derivative used as an antagonist of steroidal blockers, was studied with regard to its tendency to self-associate in aqueous solution. Three independent methods - permeation through semi-permeable cellophane membranes, dynamic light scattering, and sedimentation equilibrium analytical ultracentrifugation - were used for this purpose. The results were in agreement with each other and showed no evidence of self-association in a wide sugammadex concentration range from 0.25 to 100mg/ml.Copyright © 2011 Elsevier B.V. All rights reserved.

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