• Mohammed A Al-Biltagi, Ahmed Abd ElBasset Abo-Elezz, Rasha Mohamed Gamal Elshafiey, Ghada Abudelmomen Suliman, Maaly Mohamed Mabrouk, and Hossam Ahmed Mourad.
• Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt. Electronic address: mbelrem@hotmail.com.
• J Crit Care. 2016 Apr 1; 32: 31-5.

UnlabelledThe study aimed to evaluate the value of soluble endothelial selectin (sE-selectin) plasma level measurement in predicting acute lung injury (ALI) outcome in children.MethodsThe study was a prospective, controlled study that involved 50 children with ALI and 50 healthy children as a control. Soluble endothelial selectin and C-reactive protein plasma levels were measured at days 1 and 7 of development of ALI for the patient group and done only once for the control group.ResultsPlasma sE-selectin was significantly higher in the patients than the control group (P = .001). Mortality reached 32% of children with ALI. The deceased subgroup had significantly higher plasma sE-selectin levels both at days 1 and 7 than the survived (P = .02 and P < .001 respectively). There was positive correlation between plasma sE-selectin at day 7 with durations of both pediatric intensive care unit and mechanical ventilation. Levels of sE-selectin at days 1 and 7 had significant positive correlation with C-reactive protein level and ALI severity. Soluble endothelial selectin plasma levels of 302 ng/mL at day 7 were the best cutoff value to predict ALI-related deaths.ConclusionPlasma sE-selectin level served as a good predictor biomarker for both mechanical ventilation duration and the mortality risk in children with ALI.Copyright © 2015 Elsevier Inc. All rights reserved.

28 keywords...

hide…